Devil May Cry

The Chronicles of Vergil is a two part comic series tie-in that is a prequel to the DmC game, whose story revolves around the initial relationship between Kat and Vergil. Kat, who does not understand her psychic powers, is tracked and found by Vergil at a Virility factory. With Vergil's arrival, Kat is arrested and held under suspicion of aiding the "masked terrorist." Now dragged into Vergil's schemes, Kat will have to help Vergil find information about his long-lost brother, Dante.



DmC: Devil May Cry is a reboot disconnected from the continuity of the classic series while exploring similar themes. It starts at the beginning of Dante's exploits as a demon hunter, and depicts his growth into a figure similar to his classic counterpart.

The story takes place in Limbo City, a contemporary metropolis secretly controlled from the shadows by powerful demons, manipulating humanity through the comforts of life. Living on the fringes of the brainwashed society is Dante, a disenfranchised youth at odds with the demons who constantly hunt him and have made his life a living hell for as long as he could remember. The game's events are set into motion when Dante is taking two women from Devil's Dalliance back to his trailer home at the Bellevue Pier. After a raucous night of booze-fueled promiscuity, Dante wakes up to a young woman warning him that he's in danger. As Dante opens the door, the girl explains that he left a trail for a Hunter Demon to follow, and Dante is subsequently dragged into Limbo. After acrobatically getting dressed, Dante is guided through the Bellevue Pier's carnival by the girl, who introduces herself as Kat, a psychic medium who can see him in Limbo. Upon defeating his demon pursuer, it referred to him as "Son of Sparda," to Dante's confusion, and taunted the young man that he had been found. After returning to the human dimension, Dante is asked by Kat to come with her and meet her boss. Reluctantly, Dante accepts the proposal to repay the assistance Kat gave him at the pier.

Along the way, Kat explains that she is part of The Order, a rogue group led by who Dante calls "that masked freak on the 'net," hell-bent on exposing the demons to the world and releasing Limbo City from their clutches. The leader of The Order introduces himself as Vergil, and asks Dante about his past, which he remembers very little of thanks to a bout of meningitis when he was younger. Vergil explains that he too had lost his memory, but the instances that cause their amnesia was something only humans suffered from. Vergil explains that Dante is exceedingly important, and with his help The Order can bring down the demons. Dante scoffs at the idea, but Vergil pleads with Dante to at least let him show Dante their shared past.

Vergil, Kat, and Dante arrive at Paradise, a dilapidated mansion outside of the city that seemingly holds the key to Dante's past. There, he discovers a portrait of a man named Sparda, which he deduces to be his father. Along the way, Dante's sees apparitions of his youth, playing games with another boy named Vergil, coming to the realization that he and the white-haired man are brothers. Further investigating the mansion, Dante finds a portrait of a red-haired woman named Eva, whom he fondly remembers as his loving mother. Coming to terms with all he's learned, Dante sees more apparitions, this time of Eva screaming that "they found us" and running from armed assailants. As Limbo starts to tear apart the simulacrum of Paradise, Dante can do little but escape back to the gateway Kat made for him. Once back in the human dimension, Dante requests more information from his brother, Vergil.

Vergil obliges, taking Dante to an old playground within the city limits. Dante remembers the area as a place that Eva used to take the brothers. Looking over graffiti-slathered walls, Vergil explains how a war between angels and demons has been raging for generations, and during that time, their father Sparda had fallen in love with an angel, Eva. Eva soon gave birth to the twin boys, which infuriated the king of the demonic realm and Sparda's blood brother, Mundus. Having created a Nephilim, Sparda and Eva created the only race of being that could slay Mundus, so he attacked and killed Eva, tearing out her heart. Dante watches as his mother gave her life to protect her family, but Vergil was nowhere to be seen, so Mundus only knew of one Nephilim. As Sparda escaped with Vergil and Dante, he wiped their memories and split them up so they could attempt to live normal lives. Vergil was adopted by a wealthy family that provided for him, but Dante was unfortunately taken to a demon-run orphanage, St Lamia, where he was abused for much of his early life. Sparda returned to Mundus to prevent him from following after the children, and was sentenced to eternal torture and captivity.

Recapping their destiny, Dante asks how they can end Mundus' reign, and avenge their fallen family, but before Vergil can explain more, a Demon Collaborator finds the brothers and pulls Dante into Limbo. After fighting his way to a gate Kat made, Vergil explains to Dante the more insidious side of Mundus' actions, and outlines the plans to take out the Raptor News Network for its demonic propaganda, and the Virility Plant that brews the spiked energy drink of the same name. During Kat and Dante's journey to the Virility factory, Dante is once again pulled into the demonic dimension. As he fights his way through the twisted streets, he learns a bit more about Kat, who was taught much of her psychic abilities with Vergil's help. Once they arrive at the Virility Plant, Kat guides Dante from the mixing room and to a rift where she can spray paint a glyph to bring Dante into Limbo. From Limbo, Dante makes his way back to the mixing room, where he finds grotesque tubes feeding into the mixing tanks that people sampled cups of Virility from.

Kat helps Dante descend to the bottom of the mixing room's center air duct, where he soon confronts the "secret ingredient," a disgusting, monstrous slug-like Succubus demon hooked up to the same cords and tubes that lined the walls of the factory. During his battle with the Succubus, Dante systematically removes the demon's intubation until she falls into a river of what could only be years of her own vomit, where Dante then forces her into an industrial fan at the back of her chamber, which promptly tears her apart.

Some time later, Dante, Kat, and Vergil stand on an overpass with a clear view of the Raptor News Tower, Dante's next target. Using one of Kat's glyphs on the bridge, Dante plunges into the water below, coming out in an upside-down realm, walking along the underside of the structure. On his way to the tower, Dante is obstructed from his straight path, making his way through a penitentiary that confines human souls, and ends up coming across a helpless demon, Phineas, who lost his one good cybernetic eye to harpies. In return for retrieving Phineas' eye, the blind demon offers to help Dante. Dante follows the harpies through the subway system to their nest, where he snatches up Phineas' eye, kills the demons there, and returns to the blind prophet.

While walking with Phineas, Dante learns that Phineas was imprisoned by Mundus over a century ago, and that other Nephilim have come before the Sons of Sparda. One in particular, Assiel, did much for the world before her demise. Guiding Dante, Phineas helps the young Nephilim unleash a hidden power within him, the Devil Trigger, and then questions his purpose of targeting Barbas and Raptor News. Dante divulges his intentions of killing the demon king, and Phineas in turn divulges to Dante that Lilith, Mundus' concubine, is pregnant with an heir. Dante is unsure of what to make of Phineas' commands of killing the child, but he thanks Phineas for his help, and continues on to confront Bob Barbas in the Raptor News Tower. Dante is left pondering Phineas' parting words, "When Mundus is defeated, who will take his place?"

Within the Raptor News Tower, Dante and Barbas face off, with the demon badmouthing the young Nephilim and riling him up, even breaking up the fight to show Dante a newscast that local enforcement agencies found Kat and the ringleader of The Order, and were mobilizing on their headquarters. An angry Dante subdues Barbas with bullets from his twin pistols, and then quickly hurries back to The Order.

Dante gets pulled into Limbo upon his arrival at The Order's headquarters, just as SWAT teams are entering the compound. Dante watches in horror as the armed forces mercilessly kill any members of the Order they come across, while specifically searching for Kat. When Dante finally reaches Kat's location, she guides him down to the server room where Vergil is holed up. In the server room, Vergil helps Kat to expunge terabytes of data and back it up to a secure location, while Dante fights off incoming waves of demons. When all is done, Kat sets up the headquarters to self-destruct, and Vergil intends to leave her behind while he and Dante escape from Limbo. Dante stays behind to comfort Kat, instructing her on how to endure being taken into custody just as SWAT teams swarm through the server room, shooting Kat in the arm, and then beating her into unconsciousness as Dante watches helplessly from Limbo. With Kat dragged away, Dante meets up with Vergil.

Some time later, Vergil receives a video message of Mundus requesting to trade Kat for the Nephilim, Dante. Vergil is surprised to know that Mundus still doesn't know of his existence as a Nephilim as well, but nonetheless denies Dante the opportunity of saving Kat's life. Dante then offers up the information about Lilith and her unborn demon child, and the two brothers come to an agreement of kidnapping Lilith in exchange for bringing Mundus away from Silversacks Towers and possibly saving Kat. Dante returns to Devil's Dalliance and attempts to engage Lilith when she drags him into Limbo, and forces him to run through a Reality TV-like gauntlet in order to reach her. As Dante meets with Lilith face to face, she mutters of her intentions of bringing Dante's corpse to Mundus to earn favor, and even brings out their demon spawn to help battle the Nephilim.

Even as a gargantuan demon, the newborn and its mother are no match for Dante, and she agrees to go along quietly as long as they don't hurt the child, as Lilith says she's nothing without it. Near the shipping docks, Dante and Vergil set up their trade with SWAT for Lilith in exchange for Kat. However, during the trade, Vergil sets his scope on Lilith and blows a hole in her abdomen, killing the demon spawn, and then shooting Lilith herself in the head. In the ensuing chaos, Vergil and Dante subdue the SWAT team and save Kat. Unfortunately, Mundus watched the exchange take place, and became enraged knowing his child was killed. In response, Mundus drew power from the Hell Gate in his office, and unleashed a powerful wave of Malice that destroys most of Limbo's shipping district where the exchange took place. Dante, pulled into Limbo, runs through the crumbling streets saving Vergil and Kat in their escaping car from debris that falls into their path.

Back at the safehouse, Kat informs the twins on what she learned while being held captive in Silversacks Towers, where she used her astral projection to snoop around the grounds in Limbo. With this information, the remnants of The Order make one final attempt to reach Mundus, with Dante storming in through the front doors while Vergil sneaks in from the back, helping Dante reach higher up in the tower by taking down security protocols. Near the apex of the tower, Dante finally squares off against Drekavac a final time, routing the demon before moving on. Meeting up with Vergil, the two make their way through the Furnace of Souls, a desolate space of fiery captive souls and crag. At the top, Dante helps Vergil reactivate the generators that power the vault to Mundus' office, and once open, the two being the final phase of their plan.

Dante, tasked with drawing Mundus away from the Hell Gate, infuriates the demon king with snide comments about demon-kind and particularly Mundus' child. Mundus blasts Dante out of the office, and then rushes into him, the two of them flying out of Silversacks and onto a nearby roof. With his chance upon him, Vergil uses the Yamato to close the Hell Gate, cutting off Mundus from his immortality, and capturing his demonic soul in the human vessel Kyle Ryder. However, Mundus is still a formidable opponent, and attempts to tear out Dante's heart until he is stabbed in the back by Vergil. Mundus falls off the roof and onto a car, but instead of perishing, energy swarms around his body, and debris gathers together, forming a colossal entity of Malice, concrete, and iron. Together, the Nephilim work to take down Mundus, and expose the soul-locked body of Kyle Ryder at its core. With Mundus defeated and the Hell Gate closed, there's is nothing left to sustain Limbo, and the demonic dimension deteriorates, and demons are left in plain sight for the entire world to see.

With social media and news organizations buzzing with recent events, Dante, Kat, and Vergil look out over the city from what's left of the playground the brothers frequented as children. Vergil thanks Dante for all his help, and begins to outline his plan for ruling over humankind, which both Dante and Kat disagree with, having thought they were fighting for their freedom. Dante deduces that Vergil was only after freedom for the Nephilim, so they could live without fear of reprisal from a demon king, and Vergil claims that humans are frail, like children, and that humanity needs protection from itself. The only way to ensure that is for the Nephilim brothers to rule over the lesser race. Vergil, astounded at Dante's reaction, claims that it was them, the two Nephilim that save the humans. Angry, Dante emphasizes that without a human - Kat - they wouldn't have been able to free mankind, and would have failed miserably. Vergil states that if Dante wants no part in ruling the humans, then he should stand aside and let his brother rule alone. Dante lashes out, yelling that he didn't help his brother defeat Mundus so he could take his place, where suddenly Phineas' parting words made all too much sense.

Dante can't allow his own flesh and blood to rule over the people he had just freed, and Vergil can't let his brother obstruct his bid for domination. With the two brother's at odds, they cross swords. As the two Nephilim battled, Dante continually pleaded with his brother to reconsider, to no avail. In the end, Dante had no choice but to unleash the devil inside him and run Vergil through the heart with Rebellion. Unsure of what to do, Dante forced Vergil to the ground, impaling him with his sword until Kat begged him to let him live. Sheathing his sword, Dante helps Vergil to his feet, and declares that the world is under his protection. Vergil responds that his brother has chosen the wrong side, and that he'll never be human. Opening a dimensional rift with Yamato, Vergil mutters "I loved you, brother" before disappearing through the portal.

Dante is left questioning who he really is, and Kat succinctly replies that he is Dante—"nothing more and nothing less." With the world under his protection, Dante has many trials ahead, eradicating the scourge of demons that now exist among humankind, and coming to grips with what it means to be a Nephilim, and a Son of Sparda. The final scene shows a quick close-up of Dante's eyes, which flash with demonic power.



Vergil's Downfall is an epilogue chapter to DmC that is available as downloadable content. It tells the story of what happens to Vergil after his battle with Dante.

Fatally wounded from his battle with Dante, Vergil makes it back to Paradise but staggers to his mother's grave. As he rails against his failure, he succumbs to his injuries and collapses, falling into Hell. He soon becomes aware that his pendant is missing, and also hears a message from his departed mother that he can still find salvation despite his death. Although he attempts to follow her directions, he is cut down by the demons guarding the exit and falls further into Hell, where meets an apparition of himself named Hollow Vergil; Hollow Vergil is wearing Vergil's missing pendant, although Vergil does not appear to notice. The apparition chastises Vergil for his weakness and reveals a large disembodied heart which he claims is Vergil's; he charges Vergil with "correcting" the three holes in that heart.

As Vergil goes back to the rest of Hell, he finds what appears to be Kat and saves her from the Imprisoner who was chasing her. However, she reveals herself as nothing but a demonic apparition of his former friend, and taunts him by playing upon his anger at Kat choosing Dante over him; overcome by wrath, he slays the girl, "correcting" the first hole. Vergil then comes across an apparition of his brother, who immediately begins taunting him for being weaker and for trusting Dante. Seemingly unaware that this is not the real Dante, Vergil chases him down with the intent of slaying him as well, and eventually corners him at a replica of Assiel, where he slays the demon and takes his pendant. Frustrated when the pendant does not allow him to use his Devil Trigger, he is convinced by his doppelganger to resolve the last hole in his heart by hunting down his mother, Eva, and taking revenge on her for allegedly favoring Dante. Vergil finds his mother, this time the real article, being chased by another Imprisoner that he eventually tracks down and slays. Just as Eva expresses relief at being saved, he presents "Dante"'s pendant and claims to have killed his brother, filling her with grief. Although she explains that she always loved both her sons equally, Vergil coldly ignores her and returns to Hollow Vergil, having now completely discarded his heart and become dedicated to achieving more power.

Finally realizing that Hollow Vergil is in possession of his pendant, Vergil attacks his doppelganger and manages to defeat him, taking back the pendant and subjugating the apparition as part of his own soul. With his powers restored and his compassion gone, Vergil is returned back to where he entered Hell; he tries once again to exit Hell and this time succeeds, coming to where he originally collapsed on his mother's grave. He is approached by a horde of demons, but when they recognize his acceptance of his demonic nature, they quickly bow down to their new demonic lord.

Devil May Cry 3 begins with Dante, in his yet-to-be-named shop, where a visitor named Arkham enters and sends an invitation to Dante from his twin brother Vergil. This "invitation" is a demon attack. After Dante defeats the enemies that surround the outside of his shop, an immense tower erupts from the ground, wherein the tower is in the vicinity of the area. Sensing Vergil atop the tower, he accepts the "invitation".

At the tower's entrance, Dante encounters Cerberus(a massive 3 headed dog) who believes Dante to be a normal human so Dante defeats him. Acknowledging Dante's power, Cerberus gives Dante his soul in the form of a weapon. This turns into a pattern wherein if a certain boss is defeated, they will give Dante their souls in the form of weapons. Dante is then attacked by a woman on a motorcycle, Lady, while Dante is moving on. It is revealed later that Arkham is working for Vergil and they plan to take Dante's half of the amulet their mother gave them and use its power to reactivate the tower's ability to connect the human and demon worlds forming an action that is similar to a Hell Gate. It is also revealed that Arkham is Lady's father, that he murdered her mother, and that she is pursuing him to seek revenge.

After numerous encounters with demons while climbing the tower, Dante meets Jester, a mysterious being that resides within the tower. He also encounters Lady again who got her nickname, "Lady", from Dante because of her rejection to use her real name, Mary, that was given to her by her father. Soon, Dante reaches the tower's summit and battles Vergil. Vergil emerges victorious by stabbing Dante with his own sword. He takes Dante's half of the amulet and departs. Because Rebellion has "tasted" Dante's blood, his dormant devil powers emerge and soon sets off in pursuit of Vergil.

Arkham later on opens the door to the control room located at the tower's basement. After that, Vergil senses Arkham's apparent concern for his daughter after his failure to kill her and dispatches of Arkham as the final door is open and that he doesn't need him anymore. Dante eventually catches up to Vergil in the control room, who apparently can't reactivate the tower. Vergil battles Dante in hopes that more of Sparda's blood will make the tower reactivate, in which he implies this blood to be of his brother's. They seem evenly matched until they are interrupted by Lady after which the brothers are wounded and weak. They are soon interrupted by Jester, who knocks out Lady and reveals that he is in fact Arkham, and has been manipulating them all to reactivate the tower for his own goals. Arkham plans to go to the demon world and acquire the Force Edge which contains the bulk of Sparda's power and use it to rule over the world. He also reveals that Vergil was missing a part for the reactivation of the tower, the blood of a human priestess where it happens to be that Lady is related to the said priestess and soon sacrifices some of Lady's blood to break the spell that holds the tower. The tower then transforms, carrying Arkham upwards to the summit, while Vergil vanishes in the confusion.

Dante battles his way back up the tower, and eventually fights Lady for the right to pursue Arkham. Dante wins and Lady lends him her most powerful weapon, the Kalina Ann. Reaching the summit once again, Dante crosses over to the demon world and catches up with Arkham, who has assumed Sparda's demonic form. Overwhelmed by the power, Arkham transforms into a blob-like creature and battles Dante. Halfway through the fight, as Arkham gloats that Dante has no chance against his father's power, Vergil reappears and the two brothers fight together to defeat Arkham. Using Dante's guns, Ebony & Ivory, to finally defeat Arkham while shouting "Jackpot!". Arkham is thrown out of the demon world in a weakened state and lands atop the tower, where Lady kills him. In the demon world, Dante and Vergil battle over ownership of the Force Edge and the halves of the amulet. After an epic battle, Dante is victorious. As the portal closes, Vergil decides to stay behind, falls then vanishes into the darkness with a half of the amulet.

Returning to the human world, Dante meets Lady outside the tower where she coins the phrase "devil may cry" while trying to comfort Dante over the loss of his brother. They form a friendship and the beginnings of a partnership in demon-slaying. He later on names his shop "Devil May Cry". By accomplishing certain conditions, there is an extra scene that shows Vergil's fate. Still in the demon world severely weakened yet determined, he encounters Mundus, his father's old enemy, and charges into battle against him. His fate is later on revealed in Devil May Cry.

Devil May Cry begins with Dante being attacked in his office by a mysterious woman named Trish. He impresses her by easily brushing off her assault, and tells her that he hunts demons in pursuit of those who killed his mother and brother. She says her attack was a test, and that the demon emperor Mundus, whom Dante holds responsible for the deaths of his family, is planning a return. The scene jumps to their arrival at an immense castle, whereupon Trish abruptly leaps and vanishes over a high wall.

Dante explores the castle and encounters the game's stock enemies, the demonic Marionettes. He also finds a new sword called Alastor, and battles the first boss, a giant spider demon named Phantom. Dante wins the battle, but in what becomes a recurring theme, the defeated boss monster reappears a short time later in a corridor, forcing the player to choose a narrow escape or to fight in the tight confines. After further exploration and combat, Dante battles a demon named Nelo Angelo, who impresses Dante with his confidence. The demon wins, but suddenly flees upon seeing the half of an amulet Dante wears. The demon attacks twice more in later missions, and is eventually revealed to be Dante's identical twin brother, Vergil. After Vergil's final defeat, his amulet joins with his brother's half, and "Force Edge", the game's default sword which belonged to the twins' father, becomes the powerful Sparda sword.

When Dante next meets Trish, she betrays him and reveals that she too is working for Mundus. But when her life is endangered, Dante chooses to save her. Saying he only did so because of her resemblance to his mother, he warns her to stay away. Yet when he finally confronts Mundus, who is about to kill Trish for his plan, Dante again chooses to save her and is injured. Mundus tries to finish him off, but Trish takes the attack instead. Dante becomes enraged and unleashes his full power, a power that was inherited by Sparda. In the cutscenes, the statue starts to crack as it glows to release inside of it, Mundus spread his wings to shape the background into a dimension that he transports Dante into it. Dante questions the reason of creating Trish while Mundus rethorically answers that he could create anything, just like he created Trish for his plot to weaken Dante. With a mighty imperative word to silent the Demon Emperor, Mundus flies up to the clouds just to lure Dante. He transforms into Sparda´s form as the epic battle begins.

Dante is victorious, and leaves the amulet and sword with Trish's immobile body before departing. Later Mundus returns and corners Dante, who is now greatly weakened, before he can flee the island; but Trish comes in time and lends Dante her power. Dante defeats Mundus, who vows to return and rule the human world. When Trish tries to apologize she begins to cry, and Dante tells her it means she has become human and not just a devil, because "devils never cry". Dante and Trish escape on a plane as the island collapses. After the credits, it is revealed that Dante and Trish are working together as partners, and have renamed the shop "Devil Never Cry".

Devil May Cry 2 begins with Lucia and Dante separately entering a museum where an important item called the Arcana Medaglia is stored. After defeating a group of demons in the museum, Lucia invites Dante to follow her to the Dumary Island, where he is introduced to Matier, her mother. Matier explains that she once fought alongside Dante's father, Sparda, to defend the island against demons. She asks Dante to help fight Arius, an international businessman who uses demonic power and seeks to conquer the world. Dante flips a coin as an answer, and decides to help when the coin lands on heads. After Dante leaves Matier and Lucia discuss the Arcana, the items required for Arius to release Argosax.

Lucia eventually confronts Arius, who reveals that she was his creation. When Lucia moves to strike Arius, he uses his magic to blast her away. Shortly afterwards, Dante meets up with Lucia, who gives him the last of the Arcana before leaving. Dante then encounters Matier and tries to pass the Arcana to her. Matier, in turn, asks Dante to take the Arcana to save Lucia, who has gone to fight Arius again. Dante flips the coin again to decide if he will help; it lands on heads, and he departs to aid Lucia. Meanwhile, Lucia enters the Uroboros building and attacks Arius, who captures her. Dante arrives and trades the Arcana for Lucia, then attacks Arius. To escape, Arius forces Dante to decide between saving Lucia or killing him.

Lucia, worried about the ritual and conflicted about herself, wonders how they will stop Arius. Dante waves her off, stating he will find a way. Dante leaves Lucia to think as he departs to defeat Arius. Matier arrives a short time later, sets Lucia's mind at ease, and decides to rejoin the fight against Arius. Dante arrives to find Arius in the middle of his immortality-inducing ritual. Apparently not at all phased by the completion of the ceremony, Dante stands confident. Another fight ensues, in which Dante finishes Arius off with his pistols. Outside, Lucia confronts Dante and demands that he kill her because she fears she will become a demon herself. Before the issue can be resolved, a large stream of energy strikes the tower and a portal to the demon world is opened. Dante and Lucia argue over who will enter and close it from the inside; Dante offers to leave the issue up to fate. He flips the coin and it once again lands on heads, leaving Dante to enter the portal to deal with Argosax after leaving the coin with Lucia.

After Dante departs, Arius returns to life bearing demonic power. While Lucia fights Arius, he finds himself injured and attempts to distract her, a tactic which fails; Lucia goes on to defeat him. Within the portal, Dante fights and defeats the partially summoned Argosax. Finding the portal closed, Dante instead drives further into the demon realm on a motorcycle. In the aftermath of the battle, Matier attempts to reassure Lucia about Dante's fate, insisting that Sparda returned from a similar trip. Lucia examines the coin Dante left with her and discovers that both sides are identical. Sometime later in Dante's shop, Lucia muses about Dante. Outside the sound of a motorcycle echoes, and Lucia leaves to investigate who it is.

The game opens with Nero hurrying towards the Opera House where the Order of the Sword is conducting a ceremony, with his right arm in a sling. Meanwhile Kyrie, Nero’s romantic interest, is beginning to open the ceremony with a song and is disappointed not to find Nero in the audience. She begins her song nonetheless as Nero encounters several Scarecrow demons on his way to the Opera House. He dispatches them and arrives at the Opera House just in time to hear the end of Kyrie’s song. Following this, Kyrie joins Nero in the audience where she finds that Nero has left a present for her, a golden necklace. The High Priest of the Order of the Sword, Sanctus, beckons the Order members to join him in prayer; Nero is visibly bored by this and is about to leave despite Kyrie’s protests, when his right arm begins to glow ominously. At this moment, Dante bursts through the ceiling and assassinates Sanctus.

Nero, under the impression that Kyrie is in danger, attacks Dante to initiate a fight. As Dante gains the upper hand, Nero's right arm, the Devil Bringer, awakens and uses its power to seemingly kill Dante by impaling him with his own sword upon the statue of Sparda. Dante responds by saying that Nero is "getting better", and then pushes himself off the statue. As Dante removes the sword from his chest, Nero asks, "You're not human, are you?" Dante replies that "We're the same, you and I ... and them," pointing to one of the dead knights. Nero looks and it is revealed that the knight was possessed with a demonic appearance. Nero looks up to see that Dante is already resting on the hole in the ceiling from which he came. Dante states that he suspects Nero "carries something different from the others", and then swoops out of view just as the knight reinforcements arrive.

Nero is charged with capturing Dante and bringing him back to the Order to answer for his crimes by Credo, the leader of the Order's knights and Kyrie’s brother. Upon leaving the Opera House, however, a demonic horde begins to lay waste to the city. Nero and Kyrie are separated as Nero begins to slay the demons. Whilst journeying to Fortuna Castle he meets Gloria, a new member to the Order. Nero fights his way into the depths of Fortuna Castle. On the way, it is revealed that Sanctus has been infused with the soul of a demon to be revived. Agnus, the stuttering scientist and mastermind of the Order's demonic power manipulation, is also introduced.

Nero finally reaches Agnus's facility where he is ambushed by several white knights and is injured. Vergil's broken katana, Yamato, responds to Nero and mends itself before flying into his hand. Nero fends off Agnus' attacks with the aid of a spectral blue demon hovering behind him; after the battle, Nero collapses in exhaustion. Agnus flees back to Sanctus and informs him of Nero’s new-found power. Credo vows to take care of Nero while Gloria takes over Nero’s pursuit of Dante.

Nero is confronted by Credo, who has also been infused with demonic power, giving him the characteristics of an Angel. He is defeated by Nero, however, Kyrie arrives in time to witness Nero with his demonic arm standing over her defeated brother. Agnus uses the confusion and distraction on Nero’s part to kidnap Kyrie and flee. Credo postpones his feud with Nero until he can investigate the situation. Nero once more meets Dante, but his quest to capture him is long since forgotten; he wishes to simply pass Dante. However, Dante wants Yamato, the sword used by his twin-brother Vergil, returned to him. A fight ensues where Dante is victorious; however, he decides to let Nero keep Yamato after the latter has “cooled down”. Gloria appears before Dante as Nero leaves; however, it is revealed that Gloria is in fact Trish, Dante’s partner in his demon hunting business “Devil May Cry”.

Nero reaches Sanctus and the “Savior”, an enormous demon which the Order intends to bring to life using Nero and Yamato’s power. Using Kyrie as a human shield, Sanctus is successful in detaining Nero. Sanctus reveals that the Savior requires the essence of Sparda to reach full power; he originally intended Dante to be used as the core, but accepts Nero as a suitable substitute, claiming that Nero is also a descendant of Sparda. Credo attempts to rescue the two, but is mortally wounded by Sanctus. Dante arrives and tells Nero to give him his sword back. Nero tells Dante to "come and get it". Nero is then absorbed into the Savior. Agnus uses Yamato to open the true Hellgate, releasing a multitude of demons onto the city. Sanctus arrives with the Savior and begins to exterminate the demons. Dante, upon hearing Credo’s dying request to rescue Kyrie and Nero, fights his way back towards the city. On his way, he destroys the three smaller Hellgates used to release the demons.

Dante arrives back at the Opera House and kills Agnus. He then retrieves Yamato and uses it to destroy the true Hellgate before confronting Sanctus and the Savior. After discovering that the Savior is invincible from the outside, Dante drives Yamato into the chest of the Savior, where it is retrieved by Nero. Nero defeats Sanctus inside the Savior and rescues Kyrie. Nero eventually uses his Devil Bringer to destroy the Savior and Sanctus. After entrusting Nero with Yamato, Dante departs. Nero and Kyrie's reunion is interrupted by another demon attack. In the secret ending, at the Devil May Cry shop, Trish and Lady bicker over the small reward Lady had offered, with Lady accusing Trish for having disguised herself as Gloria and delivering Sparda's sword to the Order. After Trish forcibly drags him into their argument, Dante ends it by saying that it's "better than nothing." What's interesting is that the magazine Dante is shown reading is entitled "Two Handguns" and that two pages are entitled "Devil May Cry 4" and "Ebony and Ivory". Afterwards, Lady sets out to leave, but then the phone rings, with a customer having another job for Dante to do, and the trio moves out to help.